Abstract:Exploring the effect of influencing factors on college students' COVID-19 science popularization information seeking intention will help to carry out COVID-19 science popularization work. Currently, there is a lack of research on the role of fear in information seeking behavior. Questionnaire survey and structural equation model were used for analysis the factors influencing the intention to seeking for information about the COVID-19 vaccine in the college student group. Results have shown that perceived severity and perceived susceptibility significantly positively affect fear psychology; Fear, attitude, subjective norms, and perceived behavior control significantly positively affect the desire to search for COVID-19 vaccine health information;Facing the negative information of COVID-19 vaccine, Women are more fearful than men, age is significantly and negatively associated with fear and information seeking intention. Female and Humanities and social sciences students have stronger willingness to seeking for COVID-19 popular science information. First, the dissemination of COVID-19 vaccine science popularization information should be the primary goal of disseminating scientific knowledge, responding to public concerns, and alleviating public fears, and cut off the spread of the “infodemic”. Second, public health institutions can appropriately adopt fear appeals and focus on the role of interpersonal transmission to enhance college students' intention to seek COVID-19 vaccine science popularization information. Third, we should enhance men's willingness to seeking for science popularization information, alleviate women's fear, and carry out accurate science popularization for men and Humanities and Social Sciences College students.