Abstract:Script Murder is not only a situational role-playing game, but also a social form that Generation Z loves. The main way to spread the scientist's spirit is to tell the scientist's story, which can be used as the scene of the game, with characters and levels. This is the core point of the combination of the two parts. It combines learning and entertainment, which is in line with the characteristics of popular science education for teenagers. Based on the communication game theory, this paper discusses the rationality of integrating the spirit of scientists into the script in the content and form of popular science. It makes suggestions on the creation of narrative and game mechanics based on relevant scientist cases, which are based on scientific events and stories of scientists. It emphasizes the importance of mastering the scale of change, ensuring the truth of historical materials, scientific games and reasonable plots. Moreover, this paper discusses the effect of science popularization of the script murder of the spiritual theme of scientists according to the theory of empathy and emotion, which provides theoretical support for the realization of the concrete integration path.